TY - JOUR T1 - Screening potential biomarkers for idiopathic pulmonary fibrosis in bronchoalveolar lavage fluid JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P750 AU - Inge M. Vercauteren AU - Stijn E. Verleden AU - Bart M. Vanaudenaerde AU - Elly Vandermeulen AU - David Ruttens AU - Hannelore Bellon AU - Els De Dycker AU - Christophe Dooms AU - Jonas Yserbyt AU - Geert M. Verleden AU - Wim A. Wuyts Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P750.abstract N2 - IPF is the most lethal form of interstitial lung disease. Diagnosis is based on multidisciplinary consensus, but sensitive biomarkers are lacking.In this study Vitamin D, Krebs von den Lungen-6 (KL-6), C-peptide, Immunoglobulin E (IgE) and a fragment of Cytokeratin 19 (CYFRA21-1) were screened as possible biomarkers for IPF.Using the Lumipulse ® G1200 (Fujirebio, Ghent, Belgium) the analytes were measured in BAL samples of 83 IPF patients and 10 controls. The mean follow-up of the IPF patients was 930 days and during this timeframe 25 patients died. Lung function (FVC, FEV1, DLCO, TLC) was evaluated at the time of BAL and around 6 months after BAL sampling in the IPF patients. Survival analysis was performed for IPF patients with high concentrations of the analytes (> median concentration) and IPF patients with low concentrations (≤ median concentration).Vitamin D was not measurable and KL-6 did not significantly differ between the IPF patients and controls. However, there was a significant increase in the levels of C-peptide (p=0.0015), IgE (p=0.0006) and CYFRA21-1 (p=0.0004) in the IPF patients compared to the controls. IPF patients with high levels (> 1.2 ng/ml) of CYFRA21-1 had a worse survival than patients with lower levels of CYFRA21-1 (p=0.045). The other analytes did not correlate with the survival of the IPF patients. None of the examined analytes were predictive for the lung function evolution in the first 6 months.Of the tested analytes in BAL, CYFRA21-1 correlated with survival and therefore deserves more attention as a possible biomarker for IPF. But more validation and analysis is requested including serum measurement, other ILD types and multivariate analysis. ER -