RT Journal Article
SR Electronic
T1 Arterial oxygen content could reflect acute organ damage in community-acquired pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4647
VO 44
IS Suppl 58
A1 Francisco Sanz
A1 Laura Novella
A1 Estrella Fernandez-Fabrellas
A1 María Luisa Briones
A1 Eusebi Chiner
A1 Ruben Lera
A1 María Carmen Aguar
A1 Angela Cervera
A1 José Blanquer
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/4647.abstract
AB BackgroundArterial oxygen content (CaO2) represents the amount of oxygen delivered to the tissues. We hypothesize that low levels of CaO2 in community-acquired pneumonia (CAP) could have a systemic impact.AimsWe aim to determine the prognostic value of arterial oxygen content in CAP.Material and methodsWe analyzed CaO2 values of patients from a prospective, multicentric cohort. T student test was used to establish the relationship between CaO2 and outcomes. Percentil 50th was used to dichotomize CaO2 and compare it between the comorbidities by X2 test.ResultsFrom a population of 811 cases, CaO2 could be calculated in 632 patients. CaO2 mean and P50 values were 15.5 ml/dl (IQR 13.9-17.1). Levels of CaO2 below 15.5 ml/dl were found significantly associated with chronic heart failure (59.5% vs 47.4%; p=0.019), cerebrovascular disease (67.1 vs 46.8; p=0.001), and swallowing disorders (70.2% vs 47.3%; p=0.001). Low levels of CaO2 were associated with a worse clinical presentation (PSI IV-V 56.3% vs PSI I-III 39.5%; p=0.000). Regarding outcomes, acute renal failure was associated with low levels of CaO2 (14.8 vs 15.5; p=0.017). CaO2 levels were lower in patients who died than in survivors (14.2 vs 15.6; p=0.001).Conclusions1- Cardiovascular and neurological comorbidities showed low levels of CaO2 in CAP patients.2-Low levels of CaO2 were related to acute renal failure and mortality in our series.3-Simple measurement of arterial oxygen content could provide useful prognostic information in patients with CAP.