PT  - JOURNAL ARTICLE
AU  - Guangqiao Zeng
AU  - Baoqing Sun
AU  - Peiyan Zheng
TI  - Co-sensitization to silkworm moth (<em>Bombyx mori</em>) and 9 inhalant allergens among allergy patients in Guangzhou, Southern China
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4037
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4037.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4037.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objectives: This study aimed to investigate the profile of sensitization to silkworm moth (Bombyx mori) and other 9 common inhalant allergens among patients with allergic diseases in southern China.Methods: A total of 175 patients were tested for serum sIgE against silkworm moth in addition to combinations of other allergens: Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis, Blattella germanica, Periplaneta americana, cat dander, dog dander, Aspergillus fumigatus and Artemisia vulgaris by using the ImmunoCAP system. Correlation between sensitization to silkworm moth and to the other allergens was analyzed.Results: Of the 175 serum samples tested, 86 (49.14%) were positive for silkworm moth sIgE. With high coincidence rates, these silkworm moth sensitized patients were concomitantly sensitized to Dermatophagoides pteronyssinus (94.34%), Dermatophagoides farinae (86.57%), Blomia tropicalis (93.33%), Blattella germanica (96.08%), and Periplaneta americana (79.41%). Moreover, there was a correlation in sIgE level between silkworm moth and Dermatophagoides pteronyssinus (r = 0.518), Dermatophagoides farinae (r = 0.702), Blomia tropicalis (r = 0.701), Blattella germanica (r = 0.878), and Periplaneta americana (r = 0.531) among patients co-sensitized to silkworm moth and each of these five allergens.Conclusion: In southern Chinese patients with allergic diseases, we showed a high prevalence of silkworm moth sensitization, and a co-sensitization between silkworm moth and other five allergens. Such co-sensitization may also result from cross-reactivity of allergens, rendering future studies needed for clarification.