PT  - JOURNAL ARTICLE
AU  - Min Kwang Byun
TI  - Associations between muscle wasting and BODE index in chronic obstructive pulmonary disease
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P972
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P972.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P972.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: Muscle wasting is one of the extrapulmonary features reflects exercise capacity and physical activity in chronic obstructive pulmonary disease (COPD). To assess the muscle wasting, dynamometer handgrip strength and fat free mass (FFM) were measured. Methods: We evaluated 76 patients with stable COPD in outpatient clinic. We measured the BODE index (body mass index; BMI, the forced expiratory volume in one second; FEV1, modified medical research council scale; mMRC, 6 minute walk test; 6MWT) and COPD assessment test (CAT) score at outpatient clinic visit. The average value of 3 times handgrip strengths, the FFM were measured and compared with BODE index and CAT score. Results: The mean age was 68.8±1.3 years and 62 patients (84.2%) were male. The average of FEV1 was 66±28. Handgrip strength was well correlated with FFM (P=0.000). Handgrip strength showed significant correlations with mMRC (P=0.000) and 6MWT(P=0.013). FFM showed weak correlations with mMRC (P=0.754) and 6MWT (P=0.681). Both handgrip strength and FFM didn't show significant correlation with BODE index score (handgrip strength: P=0.191, FFM: P=0.477) and CAT score (handgrip strength: P=0.173, FFM: P=0.833). Conclusions: Handgrip strength was the reliable method to evaluate the muscle wasting in stable COPD. Handgrip strength showed a significant correlations with mMRC and 6MWT, didn't show correlations with the BODE index score and CAT score.