TY - JOUR T1 - Humoral immunity parameters in smoking and non-smoking patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P844 AU - Anatoli Tahanovich AU - Aliaksei Kadushkin Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P844.abstract N2 - Background. Cigarette smoke is the main risk factor for developing chronic obstructive pulmonary disease (COPD), however emerging evidence suggests that other risk factors are also important.Aim. The aim of the study was to investigate the levels of immunoglobulin A (IgA), IgE, IgG, IgM and percentage of B-lymphocytes in never smoking patients with COPD and COPD smokers.Methods. We examined 21 non-smokers with COPD, 20 smokers with COPD, 20 healthy non-smokers and 21 healthy smokers. Plasma levels of immunoglobulins were determined by an immunoassay technique. The analysis of B-lymphocyteswas performed using flow cytometry method.Results. Concentrations of IgA and IgE were significantly elevated in smokers with COPD compared to healthy smokers, and in non-smoking COPD patients compared to healthy non-smokers (p<0.05). Increased plasma level of IgG was observed only in smoking COPD patients compared to smoking healthy control subjects (p<0.05). There were no differences in IgM level and proportion of B-cells between the investigated groups. There was a significant positive correlation between IgE level and the number of pack-years in smoking COPD subjects (R=0.654, p=0.002).Conclusion. The results of the study support the possible role of IgA, IgE and IgG in the pathogenesis of COPD. ER -