RT Journal Article
SR Electronic
T1 Advanced glycation endproducts and lung function in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3675
VO 44
IS Suppl 58
A1 Michelle John
A1 Maath Al Haddad
A1 Sam Hussain
A1 Charlotte Bolton
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3675.abstract
AB Advanced glycation endproducts (AGE) are markers of glycaemic and oxidative stress and pro-inflammatory, leading to collagen cross-linking. Skin autofluoresence is a non-invasive measure of skin AGE, validated against skin biopsies, reflecting tissue accumulation.Hypothesis: Skin AGE is increased in patients with COPD compared to controls and inversely related to lung function.Caucasian subjects, with and without COPD, were assessed at clinical stability. Post-bronchodilator spirometry and skin AGE were performed and self-reported medical and smoking history recorded.Consenting patients with COPD, n=172 (62%male) had mean (SD) age: 68(8)yrs and FEV1%pred: 59(18)%. Controls, n=88 (60%male), were aged 66(10)yrs and FEV1%pred: 100(14)%.Skin AGE was greater in patients with COPD: 3.0(0.5)AU compared to controls 2.7(0.5)AU, p<0.01; and indirectly related to FEV1% in the total group r=-0.28, p<0.01; and in COPD alone r=-0.17, p<0.05. This was independent of age, and presence of co-morbidities of diabetes and ischaemic heart disease.There was no significant difference in skin AGE between those with IHD (n=38) and without but greater in those with diabetes (n=32) compared to those without, p<0.001 in the total group. There was no significant difference in skin AGE between current and ex-smokers.Skin AGE is increased in patients with COPD compared to controls and independently inversely associated with airways obstruction. It is a simple non-invasive tool to measure glycaemic and oxidative stress and the clinical application in COPD should be investigated further.