@article {ZhaoP719, author = {Wen Zhao and Huaping Dai and Yan Liu and Chen Wang}, title = {Clinical features of microscopic polyangiitis with usual interstitial pneumonia-like fibrosis in comparison with idiopathic pulmonary fibrosis}, volume = {44}, number = {Suppl 58}, elocation-id = {P719}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Introduction Microscopic polyangiitis (MPA) patients presented with usual interstitial pneumonia (UIP) pattern are likely misdiagnosed as idiopathic pulmonary fibrosis (IPF). Aims To explore the clinical features of MPA with UIP-like and the difference between MPA and IPF. Methods The study population was composed of 36 patients diagnosed as MPA with UIP-like pattern on chest HRCT (MPA/UIP) in Beijing Chao-Yang Hospital of Capital Medical University from Aug. 2003 to Aug. 2013 (male/female ratio, 1.77:1, age 67.25{\textpm}11.50 years). 72 patients with IPF (male/female ratio, 3.5:1, age 63.96{\textpm}10.00 years) admitted in the same time were analyzed. Results Many non-specific inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulin G, ferritin and peripheral white blood cell count, neutrophilic granulocyte percent, fibrinogen, D-dimer were increased in MPA/UIP patients (P\<0.05). Besides positive ANCA, rheumatoid factor (RF) was mostly positive in MPA/UIP patients (11/28 vs 5/52, P=0.002). Abnormal blood urea nitrogen and serum creatinine, mild anemia and hypoproteinemia and hematuria and/or proteinuria were more common in MPA/UIP patients(P\<0.05). However, serum carcinoembryonic antigen and CA199 were higher in IPF patients(P\<0.05). Conclusions MPA patients with UIP-like pattern have abnormality of more laboratory examinations and can be differentiated with IPF by comprehensive analysis of clinical and laboratory findings.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P719}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }