PT  - JOURNAL ARTICLE
AU  - Daniela Gompelmann
AU  - Ralf Eberhardt
AU  - Maren Schuhmann
AU  - Konstantina Kontogianni
AU  - Arschang Valipour
AU  - Felix J.F. Herth
TI  - Time-response course after endoscopic lung volume reduction – Analysis of the VENT trial
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3716
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3716.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3716.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objective:The VENT compared the safety and efficacy of Zephyr valve in heterogeneous emphysema to medical treatment. The time response course after the intervention, however, has not yet been addressed systematically.Methods:Patients were followed-up at 30, 90, 180 and 365 days after the intervention and the time of response, defined using validated minimal clinical important differences (MCIDs) of outcomes, was evaluated.Results:521 subjects were enrolled into the programme. An MCID of 12% were used for FEV1, -4 points for the SGRQ and a 6 MWT improvement of 26 m. The majority of the 1-year responders for SGRQ and 6MWT were responders within the first 90-days whereas the FEV1 had quite a few late (post 180-day) responders.View this table:Conclusion:The time-course of response to endoscopic lung volume reduction with the Zephyr valves varies according to selected outcomes, with quality of life and exercise capacity showing an early response compared with FEV1.