TY - JOUR T1 - Carbapenemase producing Klebsiella pneumoniae (KPC+) colonization/infection in a respiratory intensive care unit: Prevalence, length of stay(LOS) and mortality JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4693 AU - Lara Pisani AU - Luca Fasano AU - Anna Koutelou AU - Simone Ambretti AU - Viviana Ribuffo AU - Filippo Natali AU - Sara Tedeschi AU - Fabio Tumietto AU - Stefano Nava Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4693.abstract N2 - BACKGROUND. Infections by multidrug resistant (MDR) Enterobacteriaceae in patients admitted in Intensive Care Units (ICU) are rapidly increasing and have become a worrisome problem both in terms of resources allocation and in terms of patient outcome. The prognosis of KPC+ infection is poor lacking an effective treatment. There are no specific data about the prevalence of KPC+ in a Respiratory ICU (RICU) and about lower respiratory tract infection (LRTI) outcome.AIM of this study is to assess prevalence,LOS and mortality in RICU of patients colonized/infected by KPC+.METHOD. The study was performed in a RICU of a large teaching hospital over a period of 30 months. KPC+ presence was assessed by rectal swab at admission and then every seventh day and for LRTI by BAL.RESULTS. Among 547 patients admitted in our 7-bed RICU; mortality was 25% (138/547) and the average LOS was 10.8+ 8.2days.7.7% of the patients (42/547) were colonized/infected by KPC+. 10 of these 42 subjects (24%) died in the RICU. The average LOS in RICU in this group was 24.8+ 12.3days (P<0.05 vs the overall LOS). 15/42 patients had a positive BAL and LRTI; mortality in this group was 27% (4/27).CONCLUSIONS. KPC+ colonization/infection significantly prolongs RICU LOS but does not affect mortality vs the overall population. Although based on a relatively small number of cases, this observational analysis indicates that KPC+ colonization/infection is a significant burden also in a RICU, despite it does not seem to increase the mortality rate vs non-positive patients. ER -