RT Journal Article
SR Electronic
T1 The combination of low fat-free mass and high fat mass is related to functional outcome and systemic inflammation in patients with COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3570
VO 44
IS Suppl 58
A1 Pavol Joppa
A1 Frits Franssen
A1 Ruzena Tkacova
A1 Corrine Hanson
A1 Stephen Rennard
A1 Edwin Silverman
A1 Merry-Lynn McDonald
A1 Peter Calverley
A1 Emiel Wouters
A1 Erica Rutten
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3570.abstract
AB Background: In patients with COPD, low fat-free mass index(FFMI) is related to worse lung function and exercise capacity, whereas adiposity contributes to functional limitation and systemic inflammation. The combination of low FFMI with high fat mass index(FMI) results in more disability in the elderly, yet its effects in COPD remain unknown.Methods: Patients from the ECLIPSE COPD cohort were stratified according to body composition (FFMI lower than 10th, and FMI higher than 90th percentile of the age, sex and BMI-specific values from the general population of the UK Biobank) and classified as low FFMI, and high FMI, respectively. Baseline lung function, health status(SGRQ), 6-minute walking distance(6MWD) and elevated inflammatory markers(>95th percentile of values in healthy non-smokers)were recorded.Results: In 2000 participants (63.5±7.1 yrs, 66%men), FEV1, SGRQscore and 6MWD were significantly different(p<0.05 for each comparison) between patients grouped by FFMI and FMI(Table). The combined low FFMI and high FMI had the lowest FEV1 and 6MWD, the highest SGRQscore and 1.87 (95%CI,1.22-2.86,p<0.01) odds of ≥2 elevated inflammatory markers after adjustments for age, sex, pack-years and FEV1 vs normal.Conclusion: Concurrent high FMI was related to deterioration of clinically relevant outcomes and systemic inflammation in patients with COPD and low FFMI.View this table:Support: GlaxoSmithKline SCO104960,NCT00292552 and ERS STRTF2013-2399.