TY - JOUR T1 - Volumetric and scintigraphic changes following endoscopic lung volume reduction JF - European Respiratory Journal JO - Eur Respir J SP - 262 LP - 265 DO - 10.1183/09031936.00108914 VL - 45 IS - 1 AU - Carmen Pizarro AU - Hojjat Ahmadzadehfar AU - Markus Essler AU - Rolf Fimmers AU - Georg Nickenig AU - Dirk Skowasch Y1 - 2015/01/01 UR - http://erj.ersjournals.com/content/45/1/262.abstract N2 - Bronchoscopic treatment of emphysema represents an emerging therapeutic modality for advanced emphysematous lung destruction in chronic obstructive pulmonary disease (COPD). Within the proposed techniques for endoscopic lung volume reduction (ELVR), a significant amount of experience exists for the placement of endobronchial valves (EBV) (Zephyr® valves; Pulmonx, Inc., Redwood City, CA, USA) targeting atelectasis of the treated, emphysematous lobe [1, 2]. However, post-procedural clinical improvement has also been documented in patients lacking lobar exclusion 3. While volumetric and density adaptations following ELVR have repeatedly been a focus [3, 4], the interaction of volume and perfusional/ventilatory changes remains unclear. In this observational study, we defined the extent of interdependency of ELVR-mediated volumetric and scintigraphic adaptations. EBV treatment reduces target lobe volume, ventilation and perfusion with consistent redistributive pattern http://ow.ly/C95Ue ER -