TY - JOUR T1 - Club cells, CC10 and self-control at the epithelial surface JF - European Respiratory Journal JO - Eur Respir J SP - 831 LP - 832 DO - 10.1183/09031936.00089214 VL - 44 IS - 4 AU - Pieter S. Hiemstra AU - Arnaud Bourdin Y1 - 2014/10/01 UR - http://erj.ersjournals.com/content/44/4/831.abstract N2 - There has been a recent marked increase in our insight into mechanisms that control inflammation, unwanted immune responses and tissue injury. This is illustrated by the wealth of literature on the role of regulatory T- and B-cells in lung disease, but also by studies on anti-inflammatory cytokines such as interleukin (IL)-10, and products of microbial metabolism such as short-chain fatty acids. The airway epithelium also shows clear signs of self-control, and studies on the club cell 10-kDa protein (CC10; also known as e.g. club cell secretory protein or secretoglobin family 1A member 1 (SCGB1A1)) have identified it as one of the mediators involved [1]. CC10 is a main product of club cells, which are especially abundant in the peripheral airways where they contribute to maintenance of airway integrity and repair [2]. The consequences of injury to the small airways are clear from the involvement of small airway dysfunction in an increasing number of lung diseases. Moreover, a defect in the relative abundance of CC10-expressing cells in the peripheral airways of patients with asthma, chronic obstructive pulmonary disease (COPD) and post-transplant obliterative bronchiolitis was reported … ER -