PT - JOURNAL ARTICLE AU - Shital Patil AU - Sanjay Mundkar AU - Anil Jadhav AU - Nitin Kalme TI - Tuberculosis with diabetes mellitus: Does delayed sputum conversion always needs MDR evaluation? DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2613 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2613.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2613.full SO - Eur Respir J2014 Sep 01; 44 AB - Background-In India, in 2011, there were 61.3 million people living with diabetes, and 1.98 million people developing TB.Methods-Prospective study conducted at MIMSR Medical College Latur, India during Jan. 2011 to Nov. 2013 included 200 cases of Diabetes Mellitus (DM) with TB, compared with 200 cases of TB without DM. Objectives of study were to correlate impact of DM on sputum conversion rate and on clinic-radiological overlap of DM and PTB. Sputum smear AFB examinations were done at diagnosis and subsequently at completion of intensive phase. Liquid Culture DST (MGIT-960) were done in all the cases those doesn't showing sputum conversion even after extension of one month therapy post-intensive phase.Results- PTB was observed in 141 (70.5%) cases with DM as compared to 173 (86.5%) cases without DM (p<0.0002).Lower Lung fields involvement in 34 (24.11%) cases with DM and 11 (6.35%) cases without DM cases. Pulmonary Cavities were observed in 55 (39.00%) cases with DM and 49 (28.32%) cases without DM (p<0.0001). Sputum conversion percentage was observed in 76.53% Diabetes group as compared to without DM group 92.70% (p<0.003). Out of 5.2% cases which were failed to show sputum conversion in diabetic group, 2.8% cases were found to have MDR.Conclusion-DM affects the clinical, bacteriological and radiological presentation of PTB. Failure of sputum conversion should be interpreted cautiously, as many cases were showing delayed sputum conversion after extension of one month of intensive phase; this may be because of generalized immunosupression due to underlying comorbidity of DM.