%0 Journal Article %A Inga Heinzelmann %A Rainer Gloeckl %A Stella Seeberg %A Thomas Damisch %A Antje Stegemann %A Maren Plagmann %A Andreas Jerrentrup %A Klaus Kenn %T Changes in pCO2 levels during 6-minute walking test in patients with very severe COPD %D 2014 %J European Respiratory Journal %P P4495 %V 44 %N Suppl 58 %X BackgroundCurrent literature provides only scarce information on the development of carbon dioxide pressure (pCO2) in patients with COPD during physical activities. Therefore aim of this study was to investigate pCO2 levels during exercise (6-minute walking test; 6MWT) and at night rest in patients with very severe COPD.Methods75 COPD patients (age: 63±8y, FEV1: 33±9 % pred.) participated in this prospective study. PCO2 was transcutaneously measured by the Sentec® device during a 6MWT and during one night. These measurements where repeated after 1 week and mean values were used for analyses. Peak pCO2 during 6MWT was the primary outcome parameter.ResultsPatients increased their pCO2 level by 3.4±3.7 mmHg to a peak value of 43.6±6.5 mmHg during the 6MWT. A higher pCO2 during the 6MWT correlated slightly with higher perceived dyspnoe (r=0.32, p<0.05). It seems to be more likely that a higher pCO2 level during the 6MWT occurs in patients that are younger (correlation with age: r=-0.34, p<0.001) and who suffer from more airflow limitation (correlation with FEV1: r=-0.28, p<0.05). Additionally there was a positive correlation (r=0.63, p<0.0001) between the peak pCO2 values measured at night and during 6MWT. In 36% of the patients pCO2 level increased more than 5mmHg. This group of pCO2-increasers reached a level of 47.4 mmHg at the end of 6MWT.ConclusionsIn general the increase of pCO2 in patients with very severe COPD during 6MWT seems to be slight and not to cause relevant clinical symptoms. However, younger patients with more advanced airflow limitation may need special attention with regard to hypercapnia. %U