PT  - JOURNAL ARTICLE
AU  - Marcia Mernak
AU  - Fernanda Santana
AU  - Nathalia Pinheiro
AU  - Beatriz Saraiva-Ramanholo
AU  - Simone Grecco
AU  - Iolanda Tibério
AU  - Milton Martins
AU  - João Lago
AU  - Carla Prado
TI  - Lung inflammation was attenuated by sakuranetin treatment in a model of acute lung injury
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3932
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3932.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3932.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Acute lung injury (ALI) is characterized by diffuse inflammation and oxidative stress. Sakuranetin (SK) is a flavonoid widely found in Baccharis retusa plant and presents anti-inflammatory and antioxidant effects. This study evaluates the effects of preventive and therapeutic SK treatment in a model of ALI. Mice received intratracheal LPS or saline and were evaluated after 6 or 24hs to determine if lung inflammation is already present in 6hs. Animals were then treated with vehicle (LPS_VE) or SK 30min before (SK30'_LPS) or 6hs (LPS_SK6h) after LPS instillation. The bronchoalveolar lavage (BALF) and peripheral blood, exhaled nitric oxide (ENO) and the percentage of collagen fibers in alveolar septa were evaluated 24 hs after. An increase in BALF and peripheral blood neutrophils and in ENO was found 6hs after LPS (p<0.05). Table 1 show the prophylactic and therapeutic beneficial effects of SK in ALI mice. In conclusion, SK reduces inflammation and collagen deposition in a murine ALI model, pointing out SK as a potential therapeutic agent to be better investigated in ALI. Supported by FAPESP/CNPq.View this table:SK improve lung inflammation