TY - JOUR T1 - Late-breaking abstract: Elevated cardiovascular risk as measured by QRISK2 score in patients hospitalized for acute COPD exacerbation <em>versus</em> stable COPD outpatients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3589 AU - Elisa Pagliaroli AU - Divya Mohan AU - Vijay Padmanaban AU - Sarah Elkin AU - Paolo Palange AU - Michael Polkey Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3589.abstract N2 - Introduction: Cardiovascular (CV) disease is the second commonest cause of death in COPD, and exacerbations increase risk of a CV event. We wished to evaluate the QRISK2 score as a predictor of the CV risk in patients with acute COPD exacerbations versus a stable COPD cohort.Methods: We studied 180 patients hospitalized for COPD exacerbation retrospectively and 61 COPD outpatients prospectively, exacerbation free for &gt;4 weeks. Hospitalized patients were split according to the presence (Group 1) or the absence (Group 2) of previous CV events. Stable patients formed Group 3.We recorded medical history, CRP, lipids, BMI and spirometry. BNP levels were available for only 39 patients. Mann-Whitney and ANOVA tests were used for statistics.Results: Relative risk (RR), or absolute risk (AR)/theoretical risk ratio, was higher in the hospitalized group (p&lt;0.0001) and significantly different from the RR of the stable group (p&lt;0.001). The AR between Groups 1, 2 and 3 also differed.In the hospitalized patients AR correlated with BNP (r= 0.44, p=0.006), FEV1 %pred(r= 0.40, p&lt;0.0001) and FEV1/FVC (r=0.24, p=0.02), but not with CRP. No correlation was present in Group 3.Conclusion: Patients hospitalized for COPD exacerbations appear to have an higher CV risk at admission than stable COPD outpatients. For this, QRISK2 score could be a useful tool to stratify risk and guide treatment. ER -