TY - JOUR T1 - Predictors of increased daytime sleepiness in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2231 AU - Claudia Enz AU - Stefanie Zogg AU - Esther Helen Steveling AU - Selina Dürr AU - Sabrina Maier AU - David Miedinger AU - Jörg Daniel Leuppi Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2231.abstract N2 - Background: Previous reports have shown that COPD patients suffer increased daytime sleepiness. The role of underlying sleep-related breathing disorder and nocturnal activity is still unclear.Objective: The aim of this study was to identify potential predictors of subjective daytime sleepiness.Methods: Patients with stable COPD were recruited at the University Hospital in Basel, Switzerland, in a cross-sectional manner. COPD risk groups A-D were determined according to the new GOLD guidelines based on spirometry and COPD assessment test (CAT). To assess disturbed respiration and energy expenditure during sleep, ApneaLink and Sensewear Mini Armband were administered during one night. Subjective daytime sleepiness was recorded using Epworth Sleepiness Scale (ESS) (a score >10/24).Results: Data from 28 females and 34 males were analysed (n=62). Median BMI was 25 (IQR=8) kg/m2 and mean age was 65±9 yrs (range 44-90). Twenty-two patients (36%) were in COPD risk group A, twenty-eight patients (45%) in risk group B and twelve patients (19%) in risk groups C+D. Eleven patients (18%) had a pathological ESS >10/24. ESS correlated positively with CAT score (r=0.386, p<0.01) and inversely with age (r=-0.347, p<0.01). In risk group B, 36% had a pathologic ESS, whereas in risk group A no patient had a value >10/24. Multiple linear regression revealed that age (β=-0.243, p<0.05), Apnea Hypopnea Index (β=0.283, p<0.05) and CAT score (β=0.441, p<0.01) were independent predictors of ESS, while nocturnal energy expenditure showed no significant association (p=0.619).Conclusion: The present findings provide evidence that daytime sleepiness may partly be attributable to respiratory disturbances during sleep in patients with COPD. ER -