PT  - JOURNAL ARTICLE
AU  - Shenjie Tang
AU  - Lan Yao
AU  - Xiaohui Hao
AU  - Xia Zhang
AU  - Gang Liu
AU  - Xin Liu
AU  - Meiying Wu
AU  - Linhai Zen
AU  - Hua Sun
AU  - Yidian Liu
AU  - Jin Gu
AU  - Feishen Lin
AU  - Xiafang Wang
AU  - Zhanjun Zhang
TI  - Efficacy, safety and tolerability of linezolid for the treatment of XDR-TB: a study in China
AID  - 10.1183/09031936.00035114
DP  - 2015 Jan 01
TA  - European Respiratory Journal
PG  - 161--170
VI  - 45
IP  - 1
4099  - http://erj.ersjournals.com/content/45/1/161.short
4100  - http://erj.ersjournals.com/content/45/1/161.full
SO  - Eur Respir J2015 Jan 01; 45
AB  - Linezolid may be effective in treating multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We conducted a prospective, multicentre, randomised study to further evaluate the efficacy, safety and tolerability of linezolid in patients with extensively drug-resistant tuberculosis in China. 65 patients who had culture-positive sputum for extensively drug-resistant tuberculosis were randomly assigned to a linezolid therapy group or a control group. Patients in the two groups adopted a 2-year individually based chemotherapy regimen. The linezolid therapy group was given linezolid at a start dose of 1200 mg per day for a period of 4–6 weeks and this was then followed by a dose of 300–600 mg per day. The proportion of sputum culture conversions in the linezolid therapy group was 78.8% by 24 months, significantly higher than that in the control group (37.6%, p<0.001). The treatment success rate in linezolid therapy group was 69.7%, significantly higher than that in the control group (34.4%, p=0.004). 27 (81.8%) patients had clinically significant adverse events in the linezolid group, of whom 25 (93%) patients had events that were possibly or probably related to linezolid. Most adverse events resolved after reducing the dosage of linezolid or temporarily discontinuing linezolid. Linezolid containing chemotherapy for treatment of extensively drug-resistant tuberculosis may significantly promote cavity closure, increase sputum culture-conversion rate and improve treatment success rate. Prospective, multicentre, randomised study evaluating efficacy, safety and tolerability of linezolid in XDR-TB http://ow.ly/ztVfd