RT Journal Article
SR Electronic
T1 The use of capnometry for alveolar ventilation assessment in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2128
VO 44
IS Suppl 58
A1 Yuriy Feshchenko
A1 Liudmyla Iashyna
A1 Svitlana Opimakh
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2128.abstract
AB Introduction: Alveolar ventilation – is the part of the minute ventilation, that take place in gas exchange. Alveolar hypoventilation is one of the mechanisms of respiratory failure, a serious complication of chronic obstructive pulmonary disease (COPD).Aim: To explore the possibilities of capnometry to assess the effectiveness of alveolar ventilation in COPD patients.Methods: A totalof 100 COPD patients were examined (30 subjects with GOLD II, 45 – with GOLD III, and 25 – with GOLD IV stages) with the use of capnometry. An unique opportunity of capnometry to calculate CO2-free portion in exhaled air and integration to pneumotachometer allow determining: minute ventilation (VE), «dead» space volume (Vd) and «dead» space/tidal volume ratio (Vd%VT). Data are presented as mean±standard error.Results: The highest VE is in COPD IV patients – (12.6±0.6) l/min, the smallest –in COPD II patients (11.1±0.4) l/min, p<0.05. In COPD III patients VE is (12.2±0.5) l/min. Vde is the highest in COPD IV patients (264±14) ml with Vde%VT (37.2±1.4)%. In COPD III patients these indexes are (241±9) ml and (31.3±1.2)%, in COPD II patients – (236±15) ml and (27.5±1.1)% accordingly. Thus, effective alveolar ventilation in COPD IV patients is (7.9±0.4) l/min, in COPD III patients – (8.38±0.3) l/min, in COPD II patients – (8.05±0.3) l/min.Conclusions: On the average in COPD III patients increasing in minute ventilation are accompanied by improvement of alveolar ventilation, in COPD IV patients increasing VE goes through the waste "dead" space ventilation with decrease effective alveolar ventilation. Capnometry can be a useful tool to assess the effectiveness of alveolar ventilation in COPD patients.