TY - JOUR T1 - The association of „normal glucose“ with outcome in mechanically ventilated ICU patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2076 AU - Lucas Boeck AU - Hans Pargger AU - Peter Schellongowski AU - Charles-Edouard Luyt AU - Marco Maggiorini AU - Maurizio Bernasconi AU - Kathleen Jahn AU - Jean Chastre AU - Rene Lötscher AU - Evelyne Bucher AU - Nadine Cueni AU - Michael Koller AU - Annekathrin Mehlig AU - Thomas Staudinger AU - Heiner Bucher AU - Michael Tamm AU - Daiana Stolz Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2076.abstract N2 - Background: Uncontrolled hyperglycemia is associated with poor outcomes in critically ill patients. Similarly, hypoglycemia affects survival unfavourably.Objectives: To assess the association of “normal range glycemia” with complications and outcomes in mechanically ventilated ICU patients.Methods: Preliminary data from the multicentric prospective BioVent study were analysed. Only patients with glucose levels between 4.4 and 11.1 mmol/L (80 – 200 mg/dL) were investigated.Results: In 427 surgical and medical ICU patients glucose levels were analysed at ICU admission and at the start of mechanical ventilation. The distribution of glucose levels is presented in patients with and without poor outcome parameters (Figure; Levene's test for differences in variance). Whereas patients with favourable outcome have a glucose peak between 6 and 8 mmol/L (108 – 144 mg/dL), the remaining patients seem to have a rather uniform glucose distribution. The borderline glucose group (lowest and highest glucose quintile) had an increased risk of sepsis, renal failure and death within 1-year (p = 0.028, 0.020, and 0.043).Conclusions: Glucose levels at ICU admission and at start of mechanical ventilation are distributed more uniformly in patients with poor outcome parameters such as sepsis, renal failure and death within 1-year. Low-normal and high-normal glucose levels seem to be associated with more complications and worse outcome. ER -