PT  - JOURNAL ARTICLE
AU  - Nikolaeva Ekaterina
AU  - Ildar Kurmukov
AU  - Natalie Yudkina
AU  - Alexander Volkov
TI  - Exercise-induced pulmonary hypertension in patients with systemic sclerosis: Pilot-study
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2375
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2375.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2375.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension, which is associated with a poor prognosis.The aim of this study was to evaluate the comparison between risk factors and clinical parameters of exercise-induced increase in mean PAP in small group patients with SSc.We selected 19 patients with SSc (age 54 ± 11 years, all female) with normal resting mean PAP (17.2 ± 3.9 mm Hg) who underwent graded bicycle supine exercise right heart catheterization. Pulmonary artery systolic pressure, cardiac output, and other were estimated invasively. Cutoff values of mean PAP ≥30 mm Hg at peak exercise were considered exercise-induced pulmonary hypertension. The risk of PAH development was calculated by DETECT PAH risk calculator. Level of uric acid also was measured in all pts.Only 10 from 19 pts had a risk factors by DETECT calculator, but we didn't found PH at rest RHC. 9 (47%) patients showed a significant exercise-induced pulmonary hypertension, 7 hadn't changes in pressure follow exercises. 3 pts were excluded with low exercise capacity. We found that patients with EI-PH had significantly higher calculating level of PAH risk in DETECT scale than without (315 ± 20 vs 287 ± 24, p<0,05). Also we found that level of biomarkers were higher in group with EI-PH (uric acid 286±83 vs 182±58, p<0,05)Conclusion: exercise-induced increase in mean PAP occurs in almost one-half of patients with SSc with normal resting PASP. Detection of interrelation between EI-PH and risk-score and higher biomarkers level could testify that pts without PH now probably will develop it in nearest future and demand the early therapy intervention.