RT Journal Article
SR Electronic
T1 The effect of fixed mandibular advancement on regional upper airway geometry in OSA patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1529
VO 44
IS Suppl 58
A1 Olivier M. Vanderveken
A1 Wim Vos
A1 Jan De Backer
A1 Kristien Wouters
A1 Wilfried De Backer
A1 Marijke Dieltjens
A1 Marc Braem
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1529.abstract
AB RationaleObstructive sleep apnea (OSA) severity correlates with upper airway (UA) morphology. UA collapsibility however does not respond to mandibular advancement (MA) in an homogeneous way. This study investigates the regional effects in the UA of MA in a large population of OSA patients.Methods100pts were consecutively enrolled. At present baseline polysomnography (PSG) data in terms of apnea-hypopnea index (AHI) is available for 86pts. For 81pts functional CT scan analysis (FRI) is performed without and with MA set in 75% of maximal protrusion (MP). UA volume (iVuaw), resistance (iRuaw), minimal area (Amin) and the distance hyoid-spina mentalis (H-SM) are assessed (see figure). Response is defined as an increase in Amin with MA.ResultsBaseline AHI values correlate with iRuaw (R=0.38), Amin (R=-0.29) and the distance H-SM (R=0.24). MA does increase Amin (+1cm2, p=0.005). Responders (resp) have a larger forward+downward motion of the SM as compared to non-responders (nresp). iVuaw change was predominantly found in responders and was located posterior of the uvula (see figure).ConclusionsAmin and iRuaw do correlate with the severity of OSA. MA does improve these parameters. The largest changes in UA geometry were found posterior of the uvula. Next step is to investigate how these regional geometric changes with MA in situ do relate to clinical outcome.This study was funded by IWT.