TY - JOUR T1 - Tobacco and tuberculosis disease JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2611 AU - Sonia Toujani AU - Alaa Aqqad AU - Meriem Mjid AU - Nidhal Belloumi AU - Nozha Ben Salah AU - Chyrine Moussa AU - Yacine Ouahachi AU - Bechir Louzir AU - Nadia Mehiri AU - Jouda Cherif AU - Majed Beji Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2611.abstract N2 - Introduction: Over the last fifty years, a substantial body of epidemiological evidence shows that smoking is a risk factor for TB infection and disease besides many other known risks of TB such as immunodepressive and socioeconomic conditions.The aim of the present study is to evaluate the impact of smoking on clinical, radiological and bacteriological profile of tubercular patients.Method: A case-control study (TB with smoking/TB without smoking) was undrtaken. The data analysed were taken from medical records of tubercular patients hospitalized in a Pulmonary Departement.Result: In the period of study, 860 cases of TB were recorded. Males accounted for 65% of the subjects and 75% were aged between 20 and 40 years. The percentage of smokers was 70% ( study group n= 602 against contol group n= 258). The TB smoking group had a higer proportion of men (80%) and 60 %were aged between 20 and 40 years. The delay in diagnosis was greater in TB smokers (63 versus 45 days). Overall, 68 % of smokers had cavitary lesions compared with 52 % of non smokers and 86 % of smokers had a positive smear versus 78%. Smokers presented more severe lesions (30% versus 10%). Compliance was similar in the two groups.Conclusions: Smoking behavior can have a negative impact clinical course of TB. This is why TB control programs should emphasize interventions aiming in reducing tobacco exposures, especially among those at high risk for TB. ER -