RT Journal Article
SR Electronic
T1 Impact of overnight sleep on resting metabolic rate in OSA patients and controls
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1737
VO 44
IS Suppl 58
A1 Katalin Fekete
A1 Afroditi Boutou
A1 Nikolaos Chavouzis
A1 Athanasia Pataka
A1 Georgia Pitsiou
A1 Ioanna Athanasiou
A1 Theodoros Kontakiotis
A1 Paraskevi Argyropoulou
A1 Ioannis Kioumis
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1737.abstract
AB IntroductionObstructive sleep apnea (OSA) syndrome has been previously associated with sympathetic overactivity, hormonal dysregulation and metabolic abnormalities.AimTo investigate the potential variation of resting metabolic rate (RMR) just before and after an overnight sleep, in patients with OSA and in non-OSA controls.Material-MethodsThis is a nested case-control study. From a consecutive population referred for sleep evaluation between June 2007 and December 2011, subjects with OSA constituted the group of patients and subjects without OSA or other sleep disorders, the group of controls. All patients underwent anthropometric measurements, night polysomnography and evaluation of resting metabolic rate (RMR) before and after nocturnal sleep. RMR was compared before and after sleep in each group utilizing paired t-test or Wilcoxon signed rank test, according to distribution of values; level of p>0.05 was considered significant.ResultsThe study population constituted of 158 OSA patients (58.2% male; 46.7±12.2 years old) and 20 controls (90% male; 51.3±11.7 years old). In OSA patients RMR measured before and after overnight sleep was significantly different (1869.8±869.5 vs. 1709.6±685.9, p<0.001). Sub-analysis identified that pre and post differences were significant among patients with moderate (apnea/hypopnea index (AH)=15-30/h) and severe (AH>30/h) but not in the ones with mild (AH=5-15/h) syndrome. In controls no difference was noted in RMR before and after overnight sleep (1416.4±501.4 vs. 1344.2±565.2, p=0.279).ConclusionPatients with moderate or severe OSA establish a significant variation in RMR before and after overnight sleep, compared to non-OSA controls.