PT  - JOURNAL ARTICLE
AU  - Catia Cilloniz
AU  - Emilio Bouza
AU  - Inmaculada Grau
AU  - Luis Molinos
AU  - Miguel Salavert
AU  - Pedro Llinares
AU  - José Luis De la Cruz
AU  - Inmaculada Alfageme
AU  - Olga Rajas
AU  - Asunción Fenoll
AU  - Josefina Liñares
AU  - Isabel Cifuentes
TI  - Influence of comorbidities in the clinical presentation of invasive pneumococcal disease (IPD) in adults in Spain, 2010-2013. The ODIN study
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1051
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1051.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1051.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objectives: To explore comorbidities associated with the different clinical presentations of IPD in adults in Spain.Methods: A prospective, active, hospital-based surveillance of culture-confirmed IPD episodes in adults (≥18years) was performed in 9 Spanish hospitals (August 2010-June 2013). IPD was considered as isolation of S. pneumoniae from normally sterile fluids. Comorbidities, risk habits, clinical presentation [complicated pneumonia -CP-(presence of pleural effusion/empyema and/or multilobar infiltration), non-complicated pneumonia -N-CP-, meningitis -M-, primary bacteremia -PB-, peritonitis -P- and others -O-], and outcome were recorded. Comorbidities known to increase the risk of IPD were compared between the different clinical presentations.Results: Among the 637 IPD cases identified, up to 90.3% of the patients had ≥1 comorbidity and/or risk habits. Table shows comorbidities with significant association with any of the IPD clinical presentations.Severe sepsis/septic shock occurred in 22% of the patients. Overall mortality was 14.8%, being the highest in PB (21.2%) and CP (20%). Mortality in patients developing severe sepsis/septic shock was 35%.Conclusions: This is the first study that clearly demonstrates that some underlying conditions influence the clinical presentation of IPD and thus the mortality rate.