@article {CillonizP1051, author = {Catia Cilloniz and Emilio Bouza and Inmaculada Grau and Luis Molinos and Miguel Salavert and Pedro Llinares and Jos{\'e} Luis De la Cruz and Inmaculada Alfageme and Olga Rajas and Asunci{\'o}n Fenoll and Josefina Li{\~n}ares and Isabel Cifuentes}, title = {Influence of comorbidities in the clinical presentation of invasive pneumococcal disease (IPD) in adults in Spain, 2010-2013. The ODIN study}, volume = {44}, number = {Suppl 58}, elocation-id = {P1051}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Objectives: To explore comorbidities associated with the different clinical presentations of IPD in adults in Spain.Methods: A prospective, active, hospital-based surveillance of culture-confirmed IPD episodes in adults (>=18years) was performed in 9 Spanish hospitals (August 2010-June 2013). IPD was considered as isolation of S. pneumoniae from normally sterile fluids. Comorbidities, risk habits, clinical presentation [complicated pneumonia -CP-(presence of pleural effusion/empyema and/or multilobar infiltration), non-complicated pneumonia -N-CP-, meningitis -M-, primary bacteremia -PB-, peritonitis -P- and others -O-], and outcome were recorded. Comorbidities known to increase the risk of IPD were compared between the different clinical presentations.Results: Among the 637 IPD cases identified, up to 90.3\% of the patients had >=1 comorbidity and/or risk habits. Table shows comorbidities with significant association with any of the IPD clinical presentations.Severe sepsis/septic shock occurred in 22\% of the patients. Overall mortality was 14.8\%, being the highest in PB (21.2\%) and CP (20\%). Mortality in patients developing severe sepsis/septic shock was 35\%.Conclusions: This is the first study that clearly demonstrates that some underlying conditions influence the clinical presentation of IPD and thus the mortality rate.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P1051}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }