TY - JOUR T1 - Bronchogenic carcinoma between never-smoker and smoker patients: What are the difference? JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2733 AU - Rihab Bay AU - Soumaya Ben Saad AU - Hafaoua Daghfous AU - Hala Cherif AU - Fatma Tritar Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2733.abstract N2 - Introduction: Fifteen per cent of bronchogenic carcinoma (BC) occurs in never-smoker which is a defined as a subject who smoked less than 100 cigarettes in his/her lifetime.Aims: Identify risk factor and overview clinical, therapeutic and prognostic features of BC in never-smoker patients.Methods: 164 patients were treated for BC between 2006 and 2013: 29 non-smokers (G1) and 135 smokers (G2). The 2 groups (G1 and G2) were compared (age, past history, investigations, interventions, TNM stage and long term survival).Results: Mean age was 48 years in G1 and 62 years in G2 (p<0.05). Ratio sex was 0,2 in G1 and 26 in G2. Risk factor of lung cancer were environmental tobacco smoke in (13 cases), woodsmoke (4 cases). Comorbidity was more frequent in smoking group (p<0.05). Weakness was more frequent in G2 (59 % vs 64 %, p<0.05). Performance status of non-smokers was better. Squamous cell carcinoma was more frequent in G2 (23% vs 3%, (p<0.05). There were no differences between the 2 groups in the staging of tumors. 72 % of patients were treated by chemotherapy. Chemosensitivity was better in G1 (p<0.05). After chemotherapy, 10% of non-smokers and 4% of smokers had tumor stability (p<0.05). Tumor progression was noted in 73% of smokers and 52 % of non smokers (p<0.05).Conclusion: Because of less comorbidities, better PS and better chemosensitivity.BC in never-smokers have better prognosis than BC in smoker patients. ER -