TY - JOUR T1 - Experience with application of ECMO in dubl lung transplantation JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P273 AU - Mogely Khubutia AU - Alexandr Chuchalin AU - Oksana Kurilova AU - Alexandr Romanov AU - Pavel Marinin AU - Sergey Golovinskiy AU - Evgeniy Tarabrin Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P273.abstract N2 - INTRODUCTION. Lung transplantation (LTx) is the only radical method of treatment for end-stage pulmonary diseases. The most reliable intraoperative mechanical extracorporeal support is conventional cardiopulmonary bypass (CPB). However, CPB increases a risk of intraoperative bleeding and primary graft dysfunction. ECMO is more beneficial method of intraoperative cardiopulmonary support than CPB in LTx. The aim of our study is to summarize our experience with usage of ECMO in LTx.METHODS. 10 LTx were retrospectively analyzed in the period from 01.12.2012 till 01.12.014. Indications for ECMO were acute grafts edema after reperfusion (n=4,group 1). In group II (n=6) indications for ECMO were severe hypoxemia (РаO2/FiO2 ratio <1.0) and/or acidosis (pH <7.2) during one lung ventilation. We used central type of veno-arterial ECMO: right atrium to ascending aorta.RESULTS. IntraoperativeECMO lasted 4.1±1.0 in groups I and 8.5±0.7 hours in groups II. ECMO was prolonged into postoperative period in all patients from group I due to primary graft dysfunction. Application of ECMO in group II enabled to stabilize gas exchange and circulation as well as to decrease pulmonary arterial pressure in the time of reperfusion. We were able to avoid high airway pressure and high fraction of inspired oxygen during mechanical ventilation of lung grafts after connection of ECMO in patient of both groups. ECMO was finished just after transplantation in group II. The 1-year survival in groups I and II were 75.0% and 83.3% in group I and II, respectively.CONCLUSION. Central veno-arterial ECMO is an adequate method of intraoperative cardiopulmonary support in LTx. It prevents postreperfusion edema of the lung grafts. ER -