RT Journal Article SR Electronic T1 Pulmonary involvement in children with connective tissue disease JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1250 VO 44 IS Suppl 58 A1 Joanna Peradzynska A1 Anna Szylling A1 Katarzyna Krenke A1 Beata Kolodziejczyk A1 Lidia Rutkowska-Sak A1 Agnieszka Gazda A1 Marek Kulus YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P1250.abstract AB Connective tissue diseases (CTDs) are autoimmune disorders affecting most commonly skin and joints, other organs manifestation may occur, within rare, but serious are pulmonary complications. CTD's treatment also affects respiratory tract. Pulmonary involvement in children can be symptomatic or manifest only as an abnormal diagnostic tests. Study aim: to asses pulmonary involvement in children with newly diagnosed CTDs. Methods: 96 children (mean age: 13 ± 3 y; 76 girls), patients of the Dept. of Pediatric Rheumatic Diseases, Institute of Rheumatology, Warsaw and 80 control subjects (mean age 12,7 ± 2,4; 50 girls) were included in the study. Study group patients were checked for lung symptoms and signs. Chest X-ray was done. All study patients underwent spirometry and body-pletysmography. Results: Chest x- ray (abnormal in 2 cases) revealed pleural adhesions. 7 cases presented persistent cough, 10 recurrent upper respiratory tract infection, no one had complained of dyspnoea or exercise limitation. Physical examination revealed wheezing present in 1 patient. The differences between z-scores of FEV1, FEV1/FVC and MEF50 of study and control group were found. In the study group the parameters were significantly lower. There were significant differences between proportion of abnormal results between study and control group. Decreased FEV1, FEV1/FVC, MEF50 and MEF25 were observed substantially more often in study group when compared to controls. Conclusions: Children with CTDs should be screened for pulmonary changes. Although restrictive pattern of lung function is typical for CTDs, airflow limitation could be an initial abnormality.