TY - JOUR T1 - Prevalence and course of sleep-disordered breathing in acute decompensated heart failure JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2238 AU - Olaf Oldenburg AU - Jens Spießhöfer AU - Henrik Fox AU - Birgit Wellmann AU - Kristina Basic AU - Dieter Horstkotte Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2238.abstract N2 - The prevalence of sleep-disordered breathing (SDB) in acute decompensated HF (ADHF) and course during re-compensation is unknown and has been analyzed in this prospective study.Consecutive ADHF patients with clinical signs (fluid overload) and symptoms (NYHA class III or IV) of decompensated HF underwent cardiorespiratory polygraphy (PG) to determine the apnea-hypopnea index (AHI), number of oxygen desaturations (ODI) and the percentage of recording time spent with oxygen saturation <90% (T<90%). SDB was defined as AHI ≥ 5/h, apneic events were classified as obstructive (o), central (c) or mixed (m).A total of 107 patients were screened, 2 denied study participation. Of those included into the study, 11 withdrew their consent before PG study or PG recordings failed due to technical issues, in 2 patients HF deteriorated within hours, not allowing any PG study. In remaining 92 patients a PG study was performed revealing a SDB prevalence of 95.7%; AHI was 33.0 ± 21.7/h, ODI 30.3 ± 19.5/h, apnea index (AI) 15.0 ± 18.7/h, oAI 3.6 ± 8.5/h, cAI 10.1 ± 15.0/h, and mAI 1.4 ± 6.4/h. Mean oxygen saturation was 91.2 ± 3.3% and minimum 77.3 ± 9.3%, respectively. In 74 patients a second PG study was performed 2 days later, revealing no significant change in the number of respiratory events.SDB is highly prevalent in hospitalized ADHF patients. About 50% of respiratory events are apneas with the vast majority being of central origin. This prevalence and the distribution of respiratory events did not change during 2 days of intensive cardiac care with a significant decrease in body weight and a trend towards improved BNP concentrations. ER -