RT Journal Article SR Electronic T1 Genetic polymorphisms in early and late-onset bronchial asthma JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4041 VO 44 IS Suppl 58 A1 Mayra Parra Pérez A1 Marta Ferrer Galván A1 Verónica Sánchez López A1 Auxiliadora Romero Falcón A1 Juan Francisco Medina Gallardo A1 Pilar Pérez Morilla A1 Pablo Pérez Navarro A1 Francisco Javier Álvarez Gutiérrez YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P4041.abstract AB Introduction: Polymorphism ofglutathione s-transferase (GST) seem to play a role as genetical causes in the development of asthma, though earlier studies failed to demonstrate a relation between GST subclasses: GSTM1 (Glutathione S-transferase Mu 1), GSTT1 (Glutathione S-transferase theta-1) y GSTP1.5 (Glutathione S-transferase P) and asthma.Aims: We compared polymorphisms of GST in patients with early-onset asthma in infants, as well as in adults with late-onset asthma.Methods: We analyzed two cohorts of patients with asthma. One cohort included patients who developed asthma before the age of 12 years. The second cohort patients presented symptoms of asthma after the age of 20 years. We extracted DNA from blood samples. GST subtypes GSTT1, GSTM1 y GSTP1.5 were detected using Polymerase Chain Reaction (PCR). For GSTP1.5 we later realized restrictionResults: Total of 83 patients, mean age 36 (±13) years. 43 female, 39 male. 84% of patients were atopics. 72% presented rhinitis, 17% atopic dermatitis.In 40 patients onset of asthma was described before the age of 12 (mean age during survey 30(±12) years). 43 patients diagnosed with asthma after the age of 20 (mean age of onset 32(±10) years, mean current age 43(±12) years). We found significant correlation (p<0,011) between GSTM1 and early-onset asthma in 65% (26) of patients versus 37, 1% (16) in patients with late-onset asthma. There was no difference in the frequencies of GSTT1 and GSTP1.5.Conclusions: We found significant correlation between GSTM1 (null genotype) and early-onset asthma, suggesting an important genetical component in the development of asthma during infancy.