PT - JOURNAL ARTICLE AU - Mayra Parra Pérez AU - Marta Ferrer Galván AU - Verónica Sánchez López AU - Auxiliadora Romero Falcón AU - Juan Francisco Medina Gallardo AU - Pilar Pérez Morilla AU - Pablo Pérez Navarro AU - Francisco Javier Álvarez Gutiérrez TI - <em>Genetic polymorphisms in early and late-onset bronchial asthma</em> DP - 2014 Sep 01 TA - European Respiratory Journal PG - P4041 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P4041.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P4041.full SO - Eur Respir J2014 Sep 01; 44 AB - Introduction: Polymorphism ofglutathione s-transferase (GST) seem to play a role as genetical causes in the development of asthma, though earlier studies failed to demonstrate a relation between GST subclasses: GSTM1 (Glutathione S-transferase Mu 1), GSTT1 (Glutathione S-transferase theta-1) y GSTP1.5 (Glutathione S-transferase P) and asthma.Aims: We compared polymorphisms of GST in patients with early-onset asthma in infants, as well as in adults with late-onset asthma.Methods: We analyzed two cohorts of patients with asthma. One cohort included patients who developed asthma before the age of 12 years. The second cohort patients presented symptoms of asthma after the age of 20 years. We extracted DNA from blood samples. GST subtypes GSTT1, GSTM1 y GSTP1.5 were detected using Polymerase Chain Reaction (PCR). For GSTP1.5 we later realized restrictionResults: Total of 83 patients, mean age 36 (±13) years. 43 female, 39 male. 84% of patients were atopics. 72% presented rhinitis, 17% atopic dermatitis.In 40 patients onset of asthma was described before the age of 12 (mean age during survey 30(±12) years). 43 patients diagnosed with asthma after the age of 20 (mean age of onset 32(±10) years, mean current age 43(±12) years). We found significant correlation (p&lt;0,011) between GSTM1 and early-onset asthma in 65% (26) of patients versus 37, 1% (16) in patients with late-onset asthma. There was no difference in the frequencies of GSTT1 and GSTP1.5.Conclusions: We found significant correlation between GSTM1 (null genotype) and early-onset asthma, suggesting an important genetical component in the development of asthma during infancy.