PT - JOURNAL ARTICLE AU - Tadeusz Przybylowski AU - Piotr Bielicki AU - Katarzyna Hildebrand AU - Marta Kumor AU - Ryszarda Chazan TI - Response to exercise in patients with obstructive sleep apnea DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2241 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2241.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2241.full SO - Eur Respir J2014 Sep 01; 44 AB - Aim of this study was to assess cardio-pulmonary response to exercise (CPET) and the effect of continuous positive airway pressure (CPAP) on response to exercise.MethodsThe study group consisted of 140 patients (138 M, age 49±10 yrs, BMI 30±4 kg/m2). Baseline testing included polysomnography, CPET and lung function testing. The first post-CPAP testing (I) was performed in 73 patients after 4±1 weeks, second (II, n=24) after 15±3 weeks, distant tests (III) in 64 patients after 47±18 months.ResultsMean AHI was 43.6±23. In 23% of patients CPET was terminated due to increase in systolic blood pressure (BP) > 220 mmHg. Peak O2 consumption VO2peak was 29.1±6 ml/kg/min, but in 49% of patients it was < 83% pred. Patients with AHI> 40 had lower VO2peak (27.6±6 vs 30.8±6 ml/kg/min; p=0.001). During study I no changes in VO2peak were noticed, however peak sys. and dias. BP decreased 15.9±19.7 mmHg (p<0.05), 4.2±11.7 mmHg (p=0.02), respectively. Post-exercise recovery of BP and heart rate response was also faster.During study II increase in VO2peak of 4.2±5.6 ml/kg/min (p<0.05) and anaerobic threshold (1.4±0.2 vs 1.6±0.2 l/min; p<0.05) was found. During study III in CPAP users (n=30) VO2peak increased 2.7±3.3 ml/kg/min (p<0.05). In untreated patients VO2peak decreased 4.1±3.1 ml/kg/min (p<0.05).Conlusions In 50% of untreated OSAS patients a decrease in VO2peak can be expected.Increase in arterial BP pressure is a frequent reason of exercise termination.CPAP treatment attenuates BP pressure response to CPET and accelerates recovery of BP and heart rate.A failure to start the treatment of OSAS leads to a decrease in exercise tolerance.