RT Journal Article SR Electronic T1 Relationship between improved pulmonary arterial pressure and changes in interventricular septal configuration by 320-slice CT in patients under pulmonary endarterectomy JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2311 VO 44 IS Suppl 58 A1 Toshihiko Sugiura A1 Nobuhiro Tanabe A1 Yukiko Matsuura A1 Hajime Kasai A1 Naoko Kawata A1 Ayako Shigeta A1 Seiichiro Sakao A1 Yasunori Kasahara A1 Koichiro Tatsumi YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2311.abstract AB Purpose: We retrospectively determined whether changes of the curvature of the interventricular septum measured by ECG-gated 320-slice CT were influenced by improved pulmonary artery (PA) pressure in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary endarterectomy (PEA).Materials and Methods: Thirty-six patients (13 male, 59±9 yrs) with proven CTEPH underwent right heart catheterization (RHC) and double-volume retrospective ECG-gated enhanced volume scanning using 320-slice CT before and after PEA. CT images were reconstructed every 5% from 0-95% of the R-R interval, and a series of short-axis images of the heart at the level of the left ventricle papillary muscle was acquired using double-oblique multiplanar reformation. Septal bowing expressed as end-systolic curvature (reciprocal of radius [/cm]) was measured (a leftward curvature was denoted as a negative value). The relationships between septal curvature (SC) and hemodynamics measured by RHC before and after PEA were evaluated by linear regression analysis.Results: The correlation coefficients of SC with systolic PA pressure (sPAP) before and after PEA were -0.83 (P<0.001) and -0.46 (P=0.005), respectively. The correlation coefficients of SC with mean PA pressure (mPAP) before and after PEA were -0.83 (P<0.001) and -0.46 (P=0.005), respectively. The change in SC before and after PEA was also correlated with the change in sPAP (r=-0.64, P<0.001) and the change in mPAP (r=-0.65, P<0.001).Conclusions: SC based on ECG-gated 320-slice CT can be used to accurately estimate improved hemodynamics in patients undergoing PEA.