TY - JOUR T1 - PCR tests in atypical infections of respiratory tract in children and the impact of these infections on the childhood asthma JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1759 AU - Hanna Danielewicz AU - Wanda Balinska-Miskiewicz AU - Joanna Marciniak AU - Danuta Kalita AU - Anna Drabik-Chamerska AU - Andrzej Boznanski AU - Anna Debinska Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1759.abstract N2 - Background. Mycoplasma pneumoniae (Mp) is one of the most important etiological factor of atypical infection of the respiratory tract. Mp is the pathogen responsible for 40% community-acquired pneumonia in school-age children. Diagnosis of Mp infection is based on the serological examination with the immunoenzymatic assay ELISA, but as well PCR test are possible.Aim. The aim of the study was to assess the PCR assay value in the diagnostic process of Mp respiratory tract infection.Material and methods. 87 children admitted to Clinic due to acute or recurrent respiratory tract infection or chronic cough were enrolled to the study and were performed with PCR test for Mp. For further analysis 73 children were qualified, within 20% were patients with asthma. 44 children were examined with ELISA serology test for Mp.Results. In the group Mp infection was diagnosed due to serological examination in 9% of children, while the use of PCR allowed to diagnose Mp in 12 %. Children infected with Mp showed no elevated CRP, but in almost half (44%) ESR was increased together with relatively higher WBC values. Almost half of the children presented on physical examination involvement of the bronchi with auscultation findings like ronchi and/or wheezes, as well 44% were diagnosed with interstitial pneumonia. Spirometric tests analysis in children with acute Mp infection showed decreased FEV1/FVC, while those with former decreased FVC, although only few measurements were possible.Conclusion. PCR test seems to be valuable for Mp diagnosis on the beginning of the infection. High proportion of the children with Mp infection showed symptoms of bronchi involvement. ER -