TY - JOUR T1 - Association of ambient air pollution with the prevalence and incidence of COPD JF - European Respiratory Journal JO - Eur Respir J SP - 614 LP - 626 DO - 10.1183/09031936.00132213 VL - 44 IS - 3 AU - Tamara Schikowski AU - Martin Adam AU - Alessandro Marcon AU - Yutong Cai AU - Andrea Vierkötter AU - Anne Elie Carsin AU - Benedicte Jacquemin AU - Zaina Al Kanani AU - Rob Beelen AU - Matthias Birk AU - Pierre-Olivier Bridevaux AU - Bert Brunekeef AU - Peter Burney AU - Marta Cirach AU - Josef Cyrys AU - Kees de Hoogh AU - Roberto de Marco AU - Audrey de Nazelle AU - Christophe Declercq AU - Bertil Forsberg AU - Rebecca Hardy AU - Joachim Heinrich AU - Gerard Hoek AU - Debbie Jarvis AU - Dirk Keidel AU - Diane Kuh AU - Thomas Kuhlbusch AU - Enrica Migliore AU - Gioia Mosler AU - Mark J. Nieuwenhuijsen AU - Harish Phuleria AU - Thierry Rochat AU - Christian Schindler AU - Simona Villani AU - Ming-Yi Tsai AU - Elisabeth Zemp AU - Anna Hansell AU - Francine Kauffmann AU - Jordi Sunyer AU - Nicole Probst-Hensch AU - Ursula Krämer AU - Nino Künzli Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/3/614.abstract N2 - The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain. The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NOx) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) and categorised by severity in non-asthmatics. We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95% CI 1.11–2.23; and incidence: OR 1.79, 95% CI 1.21–2.68). None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments. Results from the ESCAPE study: what is the association of COPD prevalence and incidence with ambient air pollution? http://ow.ly/rQcFM ER -