RT Journal Article
SR Electronic
T1 Chronic nasal inflammation in asthmatic patients with eosinophilic granulomatosis with polyangitis (EGPA)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1766
VO 44
IS Suppl 58
A1 Manuela Latorre
A1 Veronica Seccia
A1 Federica Novelli
A1 Chiara Baldini
A1 Elena Bacci
A1 Maria Laura Bartoli
A1 Silvana Cianchetti
A1 Federico Dente
A1 Antonella Di Franco
A1 Pier Luigi Paggiaro
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1766.abstract
AB Background: nasal disease is a condition that may negative influence the asthma control and quality of life of EGPA patientsAim:to define the different nasal diseases in EGPA patients and their impact on asthma control and quality of lifeMethods:Were enrolled 37 EGPA patients and assessed:blood/sputum eosinophilia, exhaled/nasal nitric oxide(FeNO-NNO),nasal cytology, lung function, bronchial hyperreactivity and ACT test.Nasal polyps were graded according to the HOX endoscopy score.The short form (SF)-36,the Sino-Nasal Outcome Test (SNOT22) and the Asthma Quality of Life Questionnaire (AQLQ)were usedResults:the nasal disease preceded the EGPA onset of 17 yrs in mean;chronic rhinosinusitis with nasal polyps(CRSwNP)was identified in 54%, chronic rhinosinusitis in 22%, allergic rhinitis in 6% and non-allergic rhinitis with eosinophilia and neutrophilia in the 9 and6% of the cases. One patient hadn't a nasal disease.The nasal cytology was positive for eosinophils in the 67% of the patients.The majority of patients showed a moderate/severe asthma partially/poorly controlled. No correlation was found among CRSwP and blood or sputum eosinophilia,FeNO,NNO, lung function and ACT.View this table:SNOT22 was significantly correlated with SF-36 questionnaire(p<0,009)Conclusions:nasal disease represents the initial feature of EGPA, and may have a great impact on the patients quality of life and the asthma control.