PT  - JOURNAL ARTICLE
AU  - Manuela Latorre
AU  - Veronica Seccia
AU  - Federica Novelli
AU  - Chiara Baldini
AU  - Elena Bacci
AU  - Maria Laura Bartoli
AU  - Silvana Cianchetti
AU  - Federico Dente
AU  - Antonella Di Franco
AU  - Pier Luigi Paggiaro
TI  - Chronic nasal inflammation in asthmatic patients with eosinophilic granulomatosis with polyangitis (EGPA)
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1766
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1766.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1766.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: nasal disease is a condition that may negative influence the asthma control and quality of life of EGPA patientsAim:to define the different nasal diseases in EGPA patients and their impact on asthma control and quality of lifeMethods:Were enrolled 37 EGPA patients and assessed:blood/sputum eosinophilia, exhaled/nasal nitric oxide(FeNO-NNO),nasal cytology, lung function, bronchial hyperreactivity and ACT test.Nasal polyps were graded according to the HOX endoscopy score.The short form (SF)-36,the Sino-Nasal Outcome Test (SNOT22) and the Asthma Quality of Life Questionnaire (AQLQ)were usedResults:the nasal disease preceded the EGPA onset of 17 yrs in mean;chronic rhinosinusitis with nasal polyps(CRSwNP)was identified in 54%, chronic rhinosinusitis in 22%, allergic rhinitis in 6% and non-allergic rhinitis with eosinophilia and neutrophilia in the 9 and6% of the cases. One patient hadn't a nasal disease.The nasal cytology was positive for eosinophils in the 67% of the patients.The majority of patients showed a moderate/severe asthma partially/poorly controlled. No correlation was found among CRSwP and blood or sputum eosinophilia,FeNO,NNO, lung function and ACT.View this table:SNOT22 was significantly correlated with SF-36 questionnaire(p<0,009)Conclusions:nasal disease represents the initial feature of EGPA, and may have a great impact on the patients quality of life and the asthma control.