RT Journal Article
SR Electronic
T1 Late-breaking abstract: A simple algorithm for assigning individual COPD patients to specific phenotypes
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1756
VO 44
IS Suppl 58
A1 Pierre-Régis Burgel
A1 Jean-Louis Paillasseur
A1 Wim Janssens
A1 Jacques Piquet
A1 Jean-Michel Chavaillon
A1 Marc Decramer
A1 Nicolas Roche
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1756.abstract
AB Introduction: In recent years, heterogeneity of COPD patients has been examined using complex statistical methods (e.g. cluster analyses), which cannot be applied in daily practice.Aims and objectives: To develop simple algorithms allowing for assigning individual COPD patients to COPD phenotypesMethods: 2409 COPD patients were recruited in secondary and tertiary care in France and Belgium. Phenotyping was achieved using factor analysis for mixed data (FAMD) on the following data obtained at inclusion in the study: age, BMI, FEV1, dyspnea (mMRC), exacerbations/yr, presence of cardiovascular disease. Phenotypes were validated using all-cause mortality at three years. Classification and Regression Trees (CARTs) were used for the development of a simple algorithm for assigning individual patients to phenotypes. This algorithm was developed in a random sample representing 66.7% of the population (development cohort) and validated in the remaining 33.3% patients (validation cohort).Results: Cluster analysis identified 5 COPD phenotypes with markedly different rates and age of deaths. In the development cohort CART analysis identified cardiovascular comorbidities, mMRC, FEV1, BMI and age (but not exacerbations) as the key variables for determining rates and age of death in COPD patients. In the validation cohort, approximately 80% of patients could be assigned to their phenotypes using a simple algorithm based on these variables.Conclusions: The identified algorithm can now be used in other cohorts for external validation. This may represent a step towards a novel classification of COPD.