RT Journal Article
SR Electronic
T1 Assessment of the potential utility of alveolar volume (VA) as a surrogate for total lung capacity (TLC)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1273
VO 44
IS Suppl 58
A1 Lynsey Archer
A1 James Stockley
A1 Phyo Khaing
A1 Joanna Shakespeare
A1 Felix Woodhead
A1 Rhian Hughes
A1 Beatrice Downie
A1 Robert Hastings
A1 Robert Stockley
A1 David Parr
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1273.abstract
AB IntroductionMeasurement of TLC may detect restriction in patients with pulmonary fibrosis (IPF) (Boros, P.W. et al, Respiration 2004; 71:374-379) and hyperinflation in patients with COPD but is time consuming; VA may be a suitable surrogate, but may be underestimated particularly in airflow obstruction.AimTo compare VA and TLC in patients with IPF and COPDMethods51 patients with IPF and 208 with COPD underwent full lung function testing; lung volumes (via helium dilution) and carbon monoxide diffusing capacity. VA and TLC were compared using Pearson correlation and Bland Altman analysis.ResultsPulmonary fibrosis:VA correlated with TLC (r=0.98, p<0.0001). There was no difference between TLC and VA (mean=0.31L SE+/-0.03 p=0.99) and did not correlate with FEV1% predicted (r=0.0532, p=0.714).COPD:VA correlated with TLC (r=0.90, p<0.0001) but the difference (mean=1.40L SE+/-0.149) was significant (p=0.015) and correlated with FEV1% predicted (r= -0.51, p<0.0001)ConclusionVA may be a suitable surrogate for TLC in patients with IPF but not in COPD due to a significant difference between TLC and VA in COPD.