TY - JOUR T1 - Acute response of the mucociliary clearance in smokers in aerobic exercise JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 1401 AU - Fabiano Francisco Lima AU - Dionei Ramos AU - Juliana Tiyaki Ito AU - Fernanda Maria Machado Rodrigues AU - Beatriz Martins Manzano AU - Rafaela Fagundes Xavier AU - Romulo Araújo Fernandes AU - Alessandra Choqueta Toledo AU - Luiz Carlos Marques Vanderlei AU - Ercy Mara Cipulo Ramos Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/1401.abstract N2 - Introduction: Mucociliary clearance (MCC) is influenced by different stimulus. However it isn't known if MCC in smokers respond to stimulus of aerobic exercise as in nonsmokers and if this response differs to the stimulus of acute smoke and smoke associated with exercise in smokers. Aims: To evaluate acute response of the MCC in smokers and nonsmokers front moderate aerobic exercise and compare this response with acute stimulus of smoke and smoke associated with exercise. Also, investigate correlations between MCC and autonomic nervous system (ANS). Methods: 21 smokers were evaluated for MCC by saccharin transit time (STT) and the ANS by heart rate variability in four stages: after moderate aerobic exercise, after exercise followed by smoke, after acute smoke and after rest. For comparison in aerobic exercise were assessed 17 nonsmokers. For analysis between smoker's stages was used repeated measures ANOVA followed by Tukey test or Friedman test followed by Dunn's test, analysis between nonsmoker's stages the paired t test or Wilcoxon test was used. Correlations were evaluated using the Pearson or Spearman coefficients. Results: STT reduced after exercise in smokers and nonsmokers (p<0,04 and p<0,001 respectively) with similar response between them. Others stimulus also reduced the STT (p<0,001) without differences between them. STT showed negative correlation with the sympathetic activity in smokers (p<0,03) and positive correlation with the parasympathetic activity in nonsmokers (p<0,05). Conclusion: MCC responded to moderate aerobic exercise similarly in smokers and nonsmokers and this response correlated with ANS in both. MCC also responded after acute smoking and exercise followed by smoke in smokers. ER -