RT Journal Article
SR Electronic
T1 Acute response of the mucociliary clearance in smokers in aerobic exercise
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1401
VO 44
IS Suppl 58
A1 Fabiano Francisco Lima
A1 Dionei Ramos
A1 Juliana Tiyaki Ito
A1 Fernanda Maria Machado Rodrigues
A1 Beatriz Martins Manzano
A1 Rafaela Fagundes Xavier
A1 Romulo Araújo Fernandes
A1 Alessandra Choqueta Toledo
A1 Luiz Carlos Marques Vanderlei
A1 Ercy Mara Cipulo Ramos
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/1401.abstract
AB Introduction: Mucociliary clearance (MCC) is influenced by different stimulus. However it isn't known if MCC in smokers respond to stimulus of aerobic exercise as in nonsmokers and if this response differs to the stimulus of acute smoke and smoke associated with exercise in smokers. Aims: To evaluate acute response of the MCC in smokers and nonsmokers front moderate aerobic exercise and compare this response with acute stimulus of smoke and smoke associated with exercise. Also, investigate correlations between MCC and autonomic nervous system (ANS). Methods: 21 smokers were evaluated for MCC by saccharin transit time (STT) and the ANS by heart rate variability in four stages: after moderate aerobic exercise, after exercise followed by smoke, after acute smoke and after rest. For comparison in aerobic exercise were assessed 17 nonsmokers. For analysis between smoker's stages was used repeated measures ANOVA followed by Tukey test or Friedman test followed by Dunn's test, analysis between nonsmoker's stages the paired t test or Wilcoxon test was used. Correlations were evaluated using the Pearson or Spearman coefficients. Results: STT reduced after exercise in smokers and nonsmokers (p<0,04 and p<0,001 respectively) with similar response between them. Others stimulus also reduced the STT (p<0,001) without differences between them. STT showed negative correlation with the sympathetic activity in smokers (p<0,03) and positive correlation with the parasympathetic activity in nonsmokers (p<0,05). Conclusion: MCC responded to moderate aerobic exercise similarly in smokers and nonsmokers and this response correlated with ANS in both. MCC also responded after acute smoking and exercise followed by smoke in smokers.