TY - JOUR T1 - Analysis of the level of cytokines in blood serum and condensate in children with bronchopulmonary pathology JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1240 AU - Olga Alekseeva AU - Natalia Ilyenkova AU - Sergey Tereshchenko AU - Vladimir Chikunov Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1240.abstract N2 - In recent years, much attention is paid to surf markers local inflammation. The least studied is the determination of markers of inflammation cytokines in exhaled air condensate.Aim: to evaluate the correlation of changes of interleukins in exhaled air condensate and serum, to determine the possibility of use of non-invasive, as an independent, for the determination of markers of inflammation.Methods: we examined 122 children aged 6-12 years (1 group of 38 patients with acute bronchitis, 2 a group of 32 patients with asthma, 3 a group of 32 patients with congenital abnormalities of the lungs). Determination of the concentration of cytokines INFγ, IL-8, IL-6, α-TNF, IL-1β, IL-4 in the blood serum and exhaled air condensate conducted by enzyme immunoassay. The study of the degree of association between the variables was performed using Spearman correlation coefficient.Results: In the group of children with acute bronchitis between the level of cytokine serum and exhaled air condensate was a high correlation has been revealed only to IL1β, r=0,83 (p=0.01). In the group of children with asthma high correlation has been revealed to IL-4, r=0.8 in (p=0.01) and low for cytokines INFγ, IL-8, IL-6, α-TNF, IL-6. In the group of children with congenital malformations high correlation was revealed for α-TNF, IL6 and amounted, r=0.84 and r=0,86 respectively (p=0.01), the average correlation for IL1β, r =0,7 (p=0.03).Conclusions: The correlation between changes in the level of IL1β, IL-4, IL-6, α-TNF in the blood serum and exhaled air condensate. Expired air condensate can be used as an additional marker for evaluation of airway inflammation. ER -