TY - JOUR T1 - High prevalence of undiagnosed airflow obstruction in patients with ischaemic heart disease JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 2939 AU - Fanny W.S. Ko AU - Yat Yin Lam AU - Bryan P.Y. Yan AU - JoJo H.Y. Chu AU - David S.C. Hui Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/2939.abstract N2 - Introduction: Cardiovascular disease (CVS) and chronic obstructive airway disease (COPD) share the common risk factor of smoking. It would be important and interesting to assess the prevalence of undiagnosed COPD in patients with pre-existing CVS disease.Method: Patients underwent percutaneous coronary intervention (PCI) for ischaemic heart disease (IHD) between August 2009 and October 2010 with no history of obstructive lung disease (such as asthma, COPD, bronchiectasis) and aged ≥40 years were recruited. Spirometry examination was performed and blood biomarker ST2 (member of the interleukin 1 receptor family and a novel biomarker of cardiac stress) was assayed by enzyme linked immunosorbent assay.Results: 475 subjects (mean age 64±9.7, range 40-85years, 414 males, 278 current or ex-smokers) underwent successful spirometry examination. 322(67.8%), 126(26.5%), 26(5.5%) and 1(0.2%) had interventions to 1, 2, 3 and 4 cardiac vessels respectively. 51 (10.7%) subjects had undiagnosed airflow obstruction with FEV1/FVC ratio <70%. Among these 51 subjects, 14(27.5%), 23(45.1%), 14(27.5%) had FEV1 ≥80, 50-80 and 30-50% predicted normal, respectively. ST2 levels were higher in subjects with poorer lung function amongst those with airflow obstruction (median[IQR] 36.76[19.51-48.36] vs 26.18[19.72-33.55]ng/ml for FEV1 30-50 vs ≥50% predicted normal, p=0.01).Conclusion: Undiagnosed airflow obstruction is common among patients who had undergone PCI for IHD and more severe lung function impairment is associated with higher cardiac stress. ER -