PT  - JOURNAL ARTICLE
AU  - Kristin Baudiß
AU  - Sanja Cicko
AU  - Korcan Ayata
AU  - Marco Idzko
TI  - Ceramide-1-phosphate attenuates cigarette smoke induce lung inflammation
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P868
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P868.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P868.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Introduction: Sphingolipids are playing an essential role in normal cell und tissue homeostasis as well as in the development and progress of various diseases and disorders. The central molecule in the sphingolipid metabolism is ceramide, which can be converted into Shingosine-1-Phosphate (S1P) and Ceramide-1-Phosphate (C1P). While the role of S1P in the pathogenesis of airway inflammation has been extensively studied, little is known about C1P.Aim: To elucidate the role of C1P in the pathogenesis of cigarette smoke (CS)-induced lung inflammation and lung emphysema in mice.Methods: An acute and chronic cigarette smoke induced lung inflammation model in C57/BL6 mice (6-8 weeks old) were used. BALF was collected and the distribution of different cells analysed by flow cytometer. The cytokine content in BAL fluid was measured by Elisa. The internal surface area of the lung was calculated. Parametric test were applied for statistical analysis.Results: Intrapulmonary application of C1P suppressed airway inflammation of acute and chronic CS-induced mice models in vivo. C1P significantly reduced inflammatory cell numbers (p<0.01) and cytokine content (p<0.001) in the lung. C1P inhibited the CS-induced NF-kB activation in vitro and in vivo.Conclusion: In summary, C1P reduces the development of lung emphysema in a chronic smoke model. Our results suggest that C1P may have a role in limiting CS-induced lung inflammation and lung emphysema.