%0 Journal Article %A Miek Hornikx %A Hans Van Remoortel %A Heleen Demeyer %A Kristien De Bent %A Marc Decramer %A Thierry Troosters %A Wim Janssens %T Low muscle mass is a strong predictor for osteoporosis in smokers with or without COPD %D 2013 %J European Respiratory Journal %P P3707 %V 42 %N Suppl 57 %X RationaleReduced bone mineral density (BMD) is used to define osteopenia and osteoporosis. It is unclear if loss of bone mass exists in early COPD and if sarcopenia predisposes osteopenia and osteoporosis in early COPD.Methods132 (ex)-smokers were stratified by spirometry in COPD and smoking controls (SC). DXA scan measured femoral neck (FN), total femur (TF) and lumbar spine BMD. Low BMD (LBMD) was defined as T-score<-1 at one of three sites. Relative Muscle Mass Index (RASM) equals (lean mass arms+legs)/ height². Sarcopenia was defined as RASM<7.26 in men and RASM<5.45 in women. Muscle weakness (MW) equals handgrip force<70% predicted.ResultsView this table:Significant correlations were found between BMD and RASM (Figure1) and between sarcopenia and BMD (FNBMD: R=-0.25; p=0.004; TFBMD: R=-0.26; p=0.004; SBMD: R=-0.20; p=0.02). MW can act as an alternative for sarcopenia since they are correlated. (R=0.23; p=0.008). Multivariate linear regression confirmed MW to be associated with TFBMD (p=0.09), independently of COPD.ConclusionIn (ex)-smokers, BMD is associated with MW, independently of COPD. In patients with sarcopenia, training may induce additional health benefits for bone and muscle mass. %U https://erj.ersjournals.com/content/erj/42/Suppl_57/P3707.full.pdf