PT  - JOURNAL ARTICLE
AU  - Rosa M. Pacheco-Gonzalez
AU  - Manuel Sánchez-Solís
AU  - Luis García-Marcos
AU  - Virginia Pérez
AU  - Juan J. Quesada
AU  - Vicente Bosch
TI  - Lung function time change in infants born pretem with and without bronchopulmonary dysplasia
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P4661
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P4661.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P4661.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Introduction: Lung function is lower in preterm infants with bronchopulmonary dysplasia (BPD) as compared with those without BPD. This study compares how lung function changes with time in both groups.Material and methods: FVC, FEV0.5, FEF75 and FEF25-75 were measured in 51 infants born preterm (18 with BPD and 33 without BPD) by the rapid thoracic compression with raised volume technique at three time points: initial visit, and 6 and 12 months later. To check for differences troughout the year of study, ANOVA for repeated measurements was performed. In order to analyze the influence of BPD on the change over time of z-scores of those lung function parameters (corrected to the Jaëger equipment) a model was built using the generalized estimated equations method, which was adjusted for gestational age, sex, corrected age, z-score of body mass index.Results: At the moment of the first visit non-BPD patients were 4.8 (sd: 0.5) months of age and BPD 5.2 (sd: 0.6) months (p>0.05).View this table:Changes during the study year. ANOVA analysisView this table:Influence of BPD on lung function time change: GEE analysisConclusion: Except for FVC, lung flows increased during the study year in both BPD and non-BPD groups. However, those flows increased significantly more in non-BPD infants.