PT - JOURNAL ARTICLE AU - Marina Smolnikova AU - Svetlana Smirnova AU - Olga Tyutina AU - Sergey Tereshchenko TI - Immunology indices in severe bronchial asthma with different levels of disease control in children DP - 2013 Sep 01 TA - European Respiratory Journal PG - P865 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P865.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P865.full SO - Eur Respir J2013 Sep 01; 42 AB - Aim: To study the main indices of immunity, peculiarities of cytokine regulation of cellular interactions in groups of children with severe/ moderate severe atopic bronchial asthma (BA) with different levels of disease control.Methods: We have examined 2 groups of children – with controlled (n=50) and non-controlled (n=50) of severe/ moderate severe BA. Age was 10.9 ± 1.1 years. We have defined the indices of cellular link of immunity by fluorescent microscopy method using monoclonal antibodies to surface receptors. Humoral link indices and cytokines in blood had been defined by IFA.Results: We have revealed peculiarities in BA controlled and non-controlled in the indices of common IgE (227.95±24.67 against 359.6±31.2, p=0.0057), IL-4 (8.090±1.03 against 9.23±2.6, p=0.0019), TNFα (21.52±2.60 against 37.39±7.09, p=0.001). True differences between the levels of IgA, IgM, IgG, IL-10, IL-2 had not been found. We have revealed distinctions between some indices of cellular link of immunity in controlled and non-controlled BA: CD3+-cells (1467±258.02 against 837.04±3.85, p=0.014), CD4+-cells (880±13.6 against 984±12.8, p=0.007).Conclusion: There had been revealed laboratory markers of non-controlled atopic BA in children: higher level of IgE, IL-4, TNFα as well as higher number of CD3+-cells and the increase of sub-population of CD4+-cells as compared to the indices for controlled course of the disease.