PT - JOURNAL ARTICLE AU - Oguz Oben Biyikli AU - Aysegul Baysak AU - Gulfem Terek Ece AU - Adnan Tolga Oz AU - Mustafa Hikmet Ozhan AU - Afig Berdeli TI - The role of toll like receptors on tuberculosis infection DP - 2013 Sep 01 TA - European Respiratory Journal PG - 4626 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/4626.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/4626.full SO - Eur Respir J2013 Sep 01; 42 AB - Aim: One third of the world population is infected with Mycobacterium tuberculosis. It is still one of the most important reasons of morbidity and mortality and threatens the global health. A new horizon has been opened with the investigation of toll like receptors (TLR) in the in the immunopthogenesis of the disease. TLRs can recognize some of the ligands with lipoprotein structure in the bacilli and with the help of this mechanism a signal pathway is activated and cytokine production begins and natural immunity takes place. TLR-2 and TLR-4 are defined in tuberculosis. The aim of our study was to investiagate the relationship between TLR polymorphism and infection progress.Materials and Methods: TLR-2 and TLR-4 polymorphisms and allel distribution were compred to 100 healthy control subjects.Results: 19 of the 29 patients with tuberculosis had TLR-2 polymorphism. Twelve of the healthy subjects had polymorphism (p<0.001). TLR-4 polimorphism ve IFN-γ allel distribution were not statistically correlated.Conclusion: TLR agonist development, immunity, easier and faster polymorphism detection and prophilaxy are developing fields of investgation and further studies with greater number of patients are required for future studies which need to be supported with immunological parameters.