PT  - JOURNAL ARTICLE
AU  - Izabela Siemion-Szczesniak
AU  - Maria Korzeniewska-Kosela
AU  - Jan Kus
TI  - Risk factors for tuberculosis relapse in Polish patients
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2812
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2812.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2812.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: Recurrent tuberculosis is unfavorable epidemiological phenomenon because it can be associated with resistance to drugs.Objective: To identify risk factors associated with relapse in TB patients in PolandMethods: Data of 45282 cases with culture confirmed tuberculosis registered in the Central TB Register from 2002 to 2012 were analyzed according to demographic, social and clinical factors that may determine the recurrence of tuberculosis. Chi-squared test was used to assess statistical significance (SS) of each factor and multivariate analyses (MVA) to identify the independent risk factors.Results: There were 4271 relapsed cases of TB. The proportion of patients with relapse was significantly higher among: unmarried (11.8% vs. 10.7%, p<0.001), persons with lower education level (12.2% vs. 7.1%, p<0.0001), homeless (15.8% vs. 11.1%, p<0.0001), unemployed (12.8% vs. 10.7%, p<0.0001) and in men (12.8% vs. 8%, p<0.0001). Relapses were more common in patients with smear positive TB that in smear negative (12.7% vs. 9.5%, p<0.0001). Multidrug resistance (MDR) occured more frequently in previously treated cases (44.3% vs. 11.2%, p<0.0001) and patients with MDR-TB tended to relapse more frequently (44.3% vs. 11.2%, p<0.0001). Mean age of cases with relapse was 52.4 (±14 yrs), and of new cases 51.5 (±17.7) yrs, which was a statistically significant difference (p< 0.002). In MVA relapse remained significantly related to unemployment, low educational level and homelessness.Conclusion: The results of our study indicate that socio-economic deprivation is very strongly associated with relapse in TB patients in Poland, so a special attention should be put to the direct observation of treatment in these patients.